Kyle Shanahan is considered one of the smartest offensive coaches in the NFL, but according to former NFL coach Jay Gruden, if there's one situation where the 49ers coach seems to struggle, it's when he's forced to call plays while his team is trailing.

Also likely to be out is tight end George Kittle, who is doubtful and battling a hamstring issue. That will further ding the team’s offense. Defensively, star pass rusher Nick Bosa is questionable and top cornerback Charvarius Ward is also dealing with a hamstring issue.

San Francisco 49ers head coach Kyle Shanahan spoke with reporters after Friday's practice as the team prepares for its Week 3 matchup against the Los

San Francisco 49ers head coach Kyle Shanahan reveals different preparations against the Los Angeles Rams without Aaron Donald

At the end of the 49ers' 23-17 loss to the Vikings, Kyle Shanahan essentially ran out the clock on himself. The 49ers had the ball in field goal range with no t

Jimmy Garoppolo is the Los Angeles Rams' No. 2 quarterback, but that doesn't mean the former 49ers signal-caller is playing a huge role in helping his team prepare for Sunday's matchup at SoFi Stadium.