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WEB4 days ago · One sickle cell disease (SCD) patient may need as many as 50 units of blood and up to 25 units of platelets for the new cell-based gene therapies such as Casgevy and Lyfgenia to be successfully administered, according to the American Red Cross. As a part of…. September 16, 2024 Columns by Dunstan Nicol-Wilson.
Vaso-Occlusive Crisis - Sickle Cell Disease News
WEBJan 4, 2022 · A vaso-occlusive crisis, or VOC, occurs when sickled red blood cells block blood flow to the point that tissues become deprived of oxygen. This in turn sets in motion an inflammatory response as the body tries to rectify the problem. The result is substantial pain, which can affect any part of the body, but most commonly occurs in the back ...
Risk of blood clots more likely with sickle cell trait, but still low
WEB3 days ago · Still, the researchers said, the risk of these blood clots was low, occurring in just over 2% of people carrying SCT. The study, “ Ancestry-Independent Risk of Venous Thromboembolism in Individuals with Sickle Cell Trait vs. Factor V Leiden,” was published in Blood Advances. “I hope this study informs health professionals, particularly hematologists, that when thinking about risks ...
Top 10 Sickle Cell Disease Stories of 2022
WEBDec 29, 2022 · Here we’ve compiled a list of the 10 most-read articles published on our site in 2022, with a brief description of each. No. 10 — “ Trial of Cell Therapy to Raise HbF Levels Showing Potential, But Sanofi Leaving ”. SAR445136 is a gene-edited cell therapy designed to boost the production of fetal hemoglobin (HbF) in a patient’s blood ...
As Colder Weather Approaches, I Must Be Mindful of Triggers
WEBSep 22, 2021 · The cold is a known trigger of sickle cell crises. Our bodies naturally react to the cold by triggering mechanisms that preserve body heat in a process called thermoregulation. During this process, the blood vessels constrict, allowing less blood to flow through the skin. However, when this happens, it …
Stem cell transplant for sickle cell disease
WEBAug 21, 2024 · A stem cell transplant — also known as a bone marrow transplant, and more formally referred to as hematopoietic stem cell transplantation (HSCT) — is an invasive procedure that can be used to enable people with sickle cell disease (SCD) to produce healthy red blood cells. The bone marrow is home …
Infections are a silent menace for many with sickle cell disease
WEBMar 27, 2024 · Sickle cell disease predisposes people to infections and can aggravate the severity of an infection by compromising the immune system. The spleen is a vital organ in the immune system, responsible for filtering blood, removing old or damaged cells, and producing antibodies. In sickle cell disease, the sickling of red blood cells can impair ...
Here's what we can do for National Sickle Cell Awareness Month
WEB6 days ago · This year’s theme is “Sickle Cell Matters.”. For me, the month isn’t only about raising awareness; it’s also about educating the public, advocating for better healthcare, and creating meaningful change that improves the lives of people with this disease. There are four areas of action I’d like to see this month: education ...
Pandemic Leading to Fewer Hospital Stays, but More Severe Crises
WEBJan 25, 2022 · During the COVID-19 pandemic, fewer SCD patients have sought medical care for disease-related events, but hospital stays have been longer.
Blood Vessel Narrowing, Reduced Flow May Drive SCD Pain Crises
WEBJan 18, 2022 · Blood vessel narrowing due to external or internal stimuli, and the resulting reduced blood flow, may be the main drivers of the painful vaso-occlusive crises experienced by people with sickle cell disease (SCD). Inducing stimuli for such blood vessel narrowing include mental stress, pain, and extreme temperatures, either low or high.